What is Hymovis®?

Hymovis® is a sterile, nonpyrogenic, hydrogel manufactured with Hyadd4 (hexadecylamide of highly purified natural sodium hyaluronate obtained by bacterial fermentation) in an isotonic buffered solution. Thanks to the high viscosity and elasticity given by the hexadecylamide of sodium hyaluronate, Hymovis® improve the lubricating and Shock-absorbing Function Of Synovial Fluid, protecting cartilage and soft tissues against mechanical injuries. These properties, together with the prolonged residence time in the articular joints, enable Hymovis® to relieve pain and improve joint function with a short treatment regimen. Hymovis® is similar to the fluid that surrounds the joints in your body. This fluid acts as a lubricant and shock absorber for the joints. Hymovis® is used to treat Knee Pain Caused By Osteoarthritis. Hymovis® is usually given after other arthritis medications have been tried without success.

How To Use Hymovis®?

Hymovis® is a viscous (thick) gel-like sterile solution made from Highly Purified Hyaluronan that comes in 2 syringes each containing 3 ml (less than 1 teaspoon) that are injected into the knee one week apart by a trained clinical professional. Hyaluronan is a substance found naturally in the body and is present in high amounts in the fluid that fills the joints. The body’s own hyaluronan acts like a lubricant and a shock absorber in the joint, and it is needed for the joint to work properly. When you have osteoarthritis, the quality of the hyaluronan may be different from normal. If you do not understand this information or want to know more, please consult with your doctor in Wichita, KS.

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Before Taking Hymovis®

You should not be treated with Hymovis® if you are allergic to it, or if you have:

  • An allergy to gram-positive bacterial proteins.
  • A bleeding or blood clotting disorder such as hemophilia.
  • An infection in your knee or in the skin around your knee.
  • It is not known whether Hymovis® will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using Hymovis®.
  • It is not known whether hyaluronan passes into breast milk or if it could harm a nursing baby.
  • Hymovis® is not approved for use by anyone younger than 21 years old.

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Side Effects of Hymovis®:

Common side effects include but are not limited to:

  • Bruising Under The Skin
  • Irritation Of The Stomach Or Intestines
  • Itching
  • Inflammation Of The Knee Joint
  • Decreased Appetite
  • Headache
  • Nausea
  • Vomiting
  • Diarrhea
  • Stomach Cramps
  • Reactions At The Site Of The Injection
  • Hives
  • A Fever As A Result Of Taking The Medication
  • A Skin Rash
  • A Significant Type Of Allergic Reaction Called Anaphylaxis

Cautions To Take Hymovis®:

You should not receive Hymovis® if you have:

  • A Bleeding Disorder
  • Certain Allergies
  • An Infection In Your Knee
  • In The Skin Around Your Knee

You should not be treated with Hymovis® if you are allergic to it, or if you have:

  • An allergy to gram-positive bacteria proteins (ask your doctor if you are not sure)
  • A bleeding or blood clotting disorder such as hemophilia
  • An infection in your knee or in the skin around your knee
  • Tell your doctor if you are pregnant or breastfeeding
  • Tell your doctor about all the medicines you are using

Hymovis® is not approved for use by anyone younger than 21 years old.

Frequently Asked Questions

1. Who should not take Hymovis®?

Your doctor will determine if there is any reason why you should not be treated with Hymovis®. 
Hymovis® Should not be used in patients who have had any prior allergic reactions to any hyaluronan-based products. 
Signs of an allergic reaction may include swelling of your face, tongue, or throat; difficulty breathing or swallowing; shortness of breath; wheezing; chest pain; a tightness in your throat; sleepiness; rash; itching; hives; flushing and/or fever. 
Hymovis® Should not be used in patients with a knee joint infection, skin disease or infection around the area where the injection will be given. 
If you have circulatory problems in the legs, be sure to talk to your doctor about them.

2. What are risks of using Hymovis®?

The side effects sometimes seen after any joint injection, including Hymovis®, may include: pain, swelling, warmth, and redness. These symptoms are generally mild and do not last long. If needed, your doctor will recommend appropriate treatment. Rare cases of joint pain (named arthralgia) have been reported. 
If any of these symptoms or signs appears after you are given Hymovis®, or if you have any other problems, you should call your doctor.

3. What should be done after receiving Hymovis®?

It is recommended to avoid strenuous activities, such as high-impact sports (such as tennis and jogging) or prolonged weight bearing activities for approximately 48 hours following the injection. You should talk to your doctor regarding the appropriate time to resume such activities.

4. What happens if I overdose?

Since Hymovis® is usually given in a single dose, it does not have a daily dosing schedule.
If you need to receive more than one Hymovis® injection, call your doctor for the next injection appointment.

5. How Hymovis® is supplied?

Hymovis® is supplied in a set of 2 single-use 5 mL syringes, each containing a 3 mL dose of treatment to be injected one week apart. Each syringe is labeled Hymovis® for ready identification. The contents of the syringe are sterile and non-pyrogenic. The syringe components contain no latex.